Tadalafil (tadalafil) has the following contraindications:

1. Nitrate interaction

Explanation: nitrates, whether organic nitrates (e.g. isosorbide mononitrate, isosorbide dinitrate) or inorganic nitrates, are commonly used in the treatment of cardiovascular diseases, such as angina pectoris. When combined with tadalafil, they can cause excessive blood pressure reduction, which can lead to severe hypotension, dizziness, fainting, and even serious cardiovascular complications.

Clinical consequences: interaction can result in a sudden drop in systolic blood pressure, which can compromise blood flow in the brain and heart, increasing the risk of stroke or adverse cardiac events.

2. Hypersensitivity to tadalafil

Explanation: some patients may have an allergic reaction to tadalafil. This hypersensitivity may occur in the form of skin rashes, pruritus, swelling (e.g., face, tongue, throat), shortness of breath and in severe cases, anaphylactic shock.

Clinical consequences: allergic reactions may vary in severity. In mild cases, they can cause local discomfort and decrease the patient's quality of life. However, in cases of anaphylactic shock, this is a medical emergency that can be fatal if not treated immediately.

3. Caution in patients with certain serious cardiovascular diseases

Explanation

Unstable heart failure: in patients with unstable heart failure, the use of tadalafil may pose an additional risk due to its effect on circulation and blood pressure. Cardiac function is already compromised, and any further changes in hemodynamics can worsen the patient's condition.

Uncontrolled arterial hypertension: if hypertension is not adequately controlled, administration of tadalafil may cause changes in blood pressure that are difficult to manage. Tadalafil has the ability to relax smooth vascular muscles, which can affect normal blood pressure regulation in these patients.

Severe heart arrhythmias: severe cardiac arrhythmias already alter the normal electrical function of the heart. Tadalafil can influence cardiac and electrical hemodynamics, potentially exacerbating arrhythmia and increasing the risk of cardiovascular complications, such as inappropriate tachycardia or ventricular fibrillation.

Clinical consequences: these patients are at risk of deterioration of their cardiac status, which may require hospitalization, intensive care and, in some cases, surgical interventions or revascularization procedures. In addition, there is an increased risk of fatal cardiovascular events, such as myocardial infarction or cardiac arrest.

It is important for a doctor to carefully evaluate a patient before prescribing tadalafil and taking into account his medical history, medications he is currently taking, and any potential risk factors.

Talafil (Cialis) is a drug used to treat erectile dysfunction. It is not recommended for use in the following situations:

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If you have serious liver disease.

If you have low blood pressure, especially if it is caused by taking nitrate medications.

If you have a history of heart attack, stroke, or life-threatening arrhythmias.

If you are taking certain medications that interact with tadalafil, such as alpha blockers, nitroglycerin, and some antifungals.

If you are taking certain recreational drugs, such as Meth and cocaine, which can cause serious side effects when combined with tadalafil.

7. If you are pregnant or Breastfeeding.

8 if you are taking certain medications that increase your risk of developing priapism, such as trazodone and phentolamine.

It's important to talk to your doctor before using tadalafil if you have any of these conditions or take any of these medications.