Generic Tadalafil: All You Need to Know

I. Common name and trade name

1 、Define

"tadalafilo gen é rico" means "tadalafil (common name)" in Spanish. Tadalafil is a drug for the treatment of erectile dysfunction (ED) and pulmonary hypertension (PAH).

2 、The difference between brand drugs and brand drugs

The generic drug tadalafil has the same active ingredient as the brand drug (such as Xi Aili, which is one of the brand names of Tadalafil). The advantage of generic drugs is that their costs are usually low. because it does not have to bear the same high R & D and marketing costs as brand-name drugs.

Second, pharmacological action

1 、Mechanism of action on erectile dysfunction

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. During sexual stimulation, the nerve endings in the penile cavernous body release nitric oxide (NO). NO activates guanylate cyclase and increases the level of cyclic guanosine monophosphate (cGMP), which leads to smooth muscle relaxation and blood flow into the penile cavernous body, causing an erection.

Tadalafil inhibits the activity of PDE5, reduces the degradation of cGMP, maintains a high level of cGMP in the penile sponge and helps to maintain erectile function.

2 、Mechanism of action on pulmonary hypertension

-in pulmonary vascular smooth muscle cells, the activity of PDE5 affects vascular tension. Tadalafil relaxes pulmonary vascular smooth muscle and reduces pulmonary vascular resistance by inhibiting PDE5 and increasing the content of intracellular cGMP.

Usage and dosage

1 、Usage and dosage of erectile dysfunction

-when taken on demand, the initial dose is recommended as 10mg, which can be increased to 20mg or reduced to 5mg, depending on the efficacy and tolerance of the individual.

For daily use, the recommended dose is 2.5mg or 5mg at about the same time every day, regardless of when to have sex.

2 、Usage and dosage of pulmonary hypertension

For patients with pulmonary hypertension, the recommended dose of tadalafil is 40mg, once a day, different patients may need to adjust the dose according to the specific situation, and need to be used under the close monitoring of doctors.

IV. matters needing attention

1 、Contraindication

-patients who are taking any form of organic nitrates (such as nitroglycerin, isosorbide dinitrate, etc.) disable tadalafil because a combination of the two can lead to severe hypotension.

-it is forbidden for people who are allergic to tadarafi.

2 、Adverse reaction

Common adverse reactions include headache, indigestion, back pain, muscle pain, flushing, etc. A small number of patients may have visual abnormalities, hearing loss, and so on. If there are serious adverse reactions, they should seek medical advice in time.

3 、Interaction with other drugs

Tadalafil may interact with some drugs, and when used with α-receptor blockers (such as tamsulosin, etc.), it may increase the risk of hypotension and need to be used cautiously. When used with antifungal drugs (such as ketoconazole, itraconazole, etc.) or some antiviral drugs (such as ritonavir, etc.), it may affect the metabolism of tadalafil and increase the blood concentration of tadarafil. So as to increase the risk of adverse reactions.