All about Tadalafil (Not Tadafilo)

What you want to ask may be "tadalafil" (Tadalafe).

I. Pharmacological action

1. Tadalafil is a selective and reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5).

When sexual stimulation leads to local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the level of cGMP in the penile sponge, which helps relax the smooth muscle and flow blood into the penile tissue, resulting in an erection.

II. Clinical application

1 、Treatment of erectile dysfunction (ED)

Tadalafil can be taken as needed or regularly to improve the symptoms of male erectile dysfunction. When taken on demand, some time before sexual activity, tadalafil can effectively help patients obtain and maintain an erection in order to achieve a satisfactory sexual life. Regular use can have a more sustained improvement in erectile function. For example, some studies have shown that some patients take a certain dose of tadalafil regularly every week. It can improve the frequency and quality of spontaneous erection.

2 、Treatment of pulmonary hypertension (PAH)

In the treatment of pulmonary hypertension, tadalafil can dilate pulmonary vessels, reduce pulmonary artery pressure, improve pulmonary vascular resistance, thus reduce the afterload of the right ventricle, improve the exercise ability and quality of life of patients, and prolong the survival time of patients.

Third, adverse reactions

1. Common adverse reactions include headache, indigestion, back pain, myalgia, nasopharyngitis and so on.

2. A small number of patients may have visual abnormalities, such as color vision changes, blurred vision and so on. Although this situation is relatively rare, it is necessary to consult a doctor in time if there are visual problems in the course of use.

The use of tadalafil should be under the guidance of a doctor, especially for patients with underlying diseases such as cardiovascular disease, the safety of medication should be carefully evaluated.

1 、Mechanism of actionSildenafil is an oral drug mainly used in the treatment of male erectile dysfunction (ED). Sildenafil is a type 5 phosphodiesterase inhibitor (PDE5 inhibitor). Sildenafil increases the concentration of nitric oxide in the sponge by inhibiting the activity of PDE5 enzyme, thereby promoting blood flow into the penis and helping to achieve and maintain erection.

2 、Mode of useIt is usually recommended to take it about 1 hour before sexual activity, and the effect can last 4-6 hours, but the specific time and dose should be prescribed by your doctor, as individual differences may affect the efficacy and tolerance of the drug.

3 、Matters needing attentionBefore using sildenafil, doctors should be informed of their health status and other drugs being used to avoid potential drug interactions or adverse reactions, especially for patients with chronic diseases such as heart disease, high blood pressure and diabetes. It should be used under the guidance of a doctor.

4 、Side effectCommon side effects of sildenafil include headache, facial flushing, indigestion and blurred vision. These side effects are usually temporary and disappear gradually after withdrawal. If there are serious side effects or allergic reactions, you should seek medical attention immediately.

Sildenafil is an effective drug for the treatment of erectile dysfunction in men, but consult your doctor and follow your doctor's advice before using it.