tadalafila

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tadalafila

  1. 1. Basic information
  2. 2. Clinical application
  3. 3. Matters needing attention

The question you want to ask may be "tadalafil".

1. Basic information

1、medication type

- Tadalafil is a drug used to treat erectile dysfunction (ED) and is a phosphodiesterase type 5 (PDE5) inhibitor.

2、mechanism of action

- During the pathophysiological process of male erectile dysfunction, sexual stimulation will promote the release of nitric oxide (NO) from the nerve terminals and endothelial cells of the cavernous body. NO activates guanylate cyclase and increases the synthesis of cyclic guanosine phosphate (cGMP). PDE5 can decompose cGMP, resulting in limited relaxation of the smooth muscle of the corpus cavernosum. Erectile dysfunction, tadalafil selectively inhibits PDE5 to reduce the degradation of cGMP, thereby enhancing the relaxation of the smooth muscle of the corpus cavernosum and promoting blood flow into the corpus cavernosum. Help men gain and maintain erections.

2. Clinical application

1、Treatment of erectile dysfunction

- Tadalafil can be taken on demand or on a regular basis. When taken on demand, it may generally be effective if taken within about 30 minutes to 12 hours before sexual activity. Taking on a regular basis (such as taking a small dose every day) can improve vascular endothelial function to a certain extent, which may be more suitable for patients with some chronic diseases (such as diabetes, cardiovascular disease, etc.) complicated with erectile dysfunction and sexual needs.

2、Treatment of pulmonary hypertension (under specific dosage forms)

- Tadalafil can be used to treat pulmonary arterial hypertension by dilating pulmonary blood vessels and reducing pulmonary vascular resistance. However, when used for the treatment of pulmonary arterial hypertension, its dose and other aspects are different from the treatment of erectile dysfunction.

3. Matters needing attention

1、adverse reactions

- Common adverse reactions include headache, flushing, indigestion, nasal congestion, muscle pain, etc. These adverse reactions are usually mild to moderate and are mostly transient.

2、contraindications

- Patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide mononitrate, etc.) should not use tadalafil because their combination may cause severe hypotension and cannot be used by people allergic to tadalafil.

3、interactions with other medicinal products

- When tadalafil is co-administered with some anti-hypertensive drugs (such as alpha-blockers, etc.), the dose may need to be adjusted carefully because it may enhance the antihypertensive effect. Co-administered with CYP3A4 inhibitors (such as ketoconazole, ritonavir, etc.) may increase the plasma concentration of tadalafil and increase the risk of adverse reactions.


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