Tadalafila: What You Need to Know
The question you want to ask may be "tadalafil".
1. Basic information
1、drug classes
- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and can also be used to treat lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH).
2、mechanism of action
- Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor. During sexual stimulation, nitric oxide (NO) is released from the neuron terminals in the corpus cavernosum of the penis. NO activates guanylate cyclase, increasing the level of cyclic guanosine phosphate (cGMP), leading to relaxation of smooth muscles and blood flowing into penile tissue to produce erection. PDE5 degrades cGMP. Tadalafil inhibits the activity of PDE5, thereby increasing the concentration of cGMP and maintaining penile erectile function.
2. Usage related
1、Dosage and Administration
- For the treatment of erectile dysfunction: When taken as needed, the recommended starting dose is 10mg. Take it before sexual life. Depending on individual efficacy and tolerability, the dose can be increased to 20mg or reduced to 5mg. The maximum frequency of medication is once a day.
- Treatment of benign prostatic hyperplasia: The recommended dose is 5mg once daily.
2、adverse reactions
- Common adverse reactions include headache, indigestion, back pain, myalgia, nasal congestion, flushing, etc. These adverse reactions are usually mild or moderate and generally disappear on their own after drug discontinuation.
- Rare but serious adverse reactions include sudden loss of vision (non-arterial anterior ischemic optic neuropathy). Although this condition is very rare, patients taking tadalafil should immediately discontinue use and seek medical attention if they experience sudden loss of vision.
3、contraindications
- Tadalafil is contraindicated for patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide mononitrate, etc.) because their combination may cause severe hypotension.
- It is contraindicated for people allergic to tadalafil.
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